Pancreas Pathology

Researchers at the Institute of Diabetes Research utilize ZEISS Axioscan for whole slide imaging to study the pancreas’s islets in type 1 diabetes. This work focuses on interferon sensors, providing novel insights into autoimmunity-linked insulin production disruptions.

Whole Slide Imaging Unveils Diabetes Insights

Key Takeaways

Research focus: Whole slide imaging of pancreas using ZEISS Axioscan.
Model system: Islets of Langerhans in the pancreas.
Research goal: Analyze interferon sensors for type 1 diabetes insights.
Presenter: Dr. Teresa Rodriguez-Calvo, Institute of Diabetes Research.
Content type: Scientific Article on diabetes pathology analysis.

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2 min read

Whole Slide Imaging of the Pancreas to Study Type 1 Diabetes

Researchers investigate interferon sensors in the islets of Langerhans using automated, whole slide imaging for the study and analysis of pancreas pathology.

Type 1 diabetes is a chronic autoimmune disease in which the pancreas produces little or no insulin. Insulin is a hormone needed to allow sugar to enter cells to produce energy. The exact cause of type 1 diabetes is unknown. Usually, the body’s own immune system mistakenly destroys the insulin-producing cells (called beta cells) in the islets of Langerhans of the pancreas.

Dr. Teresa Rodriguez-Calvo of the Institute of Diabetes Research (Helmholtz Zentrum München), Germany, heads a lab focused on increasing our understanding of the immunopathogenesis of human type 1 diabetes in order to develop novel therapies aimed at increasing insulin secretion and stopping the autoimmune attack.

In her recent publication, her team investigates interferon sensors in the islets of Langerhans and uses whole slide imaging with ZEISS Axioscan for the study and analysis of pancreas pathology.

The islets of Langerhans from a non-diabetic donor showing normal HLA-I expression (top), and a type 1 diabetic donor with high expression of the interferon sensor HLA-I (bottom). Scale bars are 100 μm. Image collected using automated whole slide scanning with ZEISS Axioscan.

Dr. Teresa Rodriguez-Calvo, Institute of Diabetes Research (Helmholtz Zentrum München), Germany

A whole pancreatic tissue section. Each positive islet was assigned a colored circle based on the number of expressed interferon response markers as follows: red for the expression of one marker, yellow for two markers, purple for three markers, and blue for four markers. Scale bar is 290 microns.

Upper inset of A whole pancreatic tissue section. Each positive islet was assigned a colored circle based on the number of expressed interferon response markers as follows: red for the expression of one marker, yellow for two markers, purple for three markers, and blue for four markers. Scale bar is 290 microns.

Middle inset of A whole pancreatic tissue section. Each positive islet was assigned a colored circle based on the number of expressed interferon response markers as follows: red for the expression of one marker, yellow for two markers, purple for three markers, and blue for four markers. Scale bar is 290 microns.

Lower inset of A whole pancreatic tissue section. Each positive islet was assigned a colored circle based on the number of expressed interferon response markers as follows: red for the expression of one marker, yellow for two markers, purple for three markers, and blue for four markers. Scale bar is 290 microns.

https://www.zeiss.com/microscopy/en/resources/insights-hub/life-sciences/whole-slide-imaging-pancreas.html

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Pancreas Pathology | Axioscan

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