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Explore how AI-driven 3D/4D image analysis revolutionizes drug discovery using complex in vitro models. Discover methods for capturing detailed 3D cellular structures, crucial for improving drug testing and disease research.

Unlock Drug Discovery with AI-enhanced 3D/4D Imaging

Key Takeaways

  • Focus: Advancing drug discovery with AI in 3D/4D imaging.
  • Model system: Complex in vitro models (CIVM).
  • Research goal: Enhance drug testing and disease research via detailed cellular analysis.
  • Presented by: ZEISS experts on AI-driven imaging techniques.
  • Content type: Educational Webinar on microscopy advancements.
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2 min read

The FDA's approval of organoids in preclinical research has catalyzed a major shift toward complex in vitro models (CIVM) for drug testing and disease research. The implementation of more biologically relevant phenotypic model formats, however, requires an evolution of imaging and analysis techniques. Traditional 2D high-content analysis (HCA) approaches fall short when it comes to capturing 3D biological information in detail, and many 3D cell culturing methods suffer from high sample variability. Modern microscopy systems now generate detailed 3D/4D datasets of CIVM, offering unprecedented insights into cellular structures. This webinar will explore cutting-edge tools and technologies that address these challenges, enabling researchers to use Ai-driven image analysis harness the full potential of CIVM for drug discovery and development.

Key Learnings:

  • Automation of complex in vitro model generation and quantification at scale.
  • Brightfield and fluorescent imaging techniques for 3D cell culture capturing.
  • AI and parallel computing for robust 3D hydrogel culture analysis.
  • Efficient drug response pattern detection across large 3D imaging datasets.
Danielle Mandikian, Genentech
Scalable image analysis to shorten time to results. Graphic representation of the image analysis journey from left to right. Images are created and stored in diverse equipment. The images are analyzed with automated workflows. Then all images and workflows can be sent into a central hub for processing and batch analysis that scaled up to thousand of images, for faster reproducible results.
Two lab technicians in white coats examine a digital image of a cross-section on a computer screen. One technician is seated while the other points to the screen.
Desktop monitor showing a screen of the ZEISS arivis Cloud software, with segmentation predictions of endothelial cells. Each cell is detected as a separate object.
Desktop monitor showing a screen of the ZEISS arivis Hub with analysis results of well plate - phenotypic screening, including segmentation results.
Desktop monitor showing a screen of the ZEISS arivis Pro software with analysis results of nuclear pore complexes of FIB-SEM volume electron microscopy data.
https://www.zeiss.com/microscopy/en/resources/insights-hub/life-sciences/advancing-drug-discovery-by-combining-civms-with-ai-powered-3d4d-image-analysis.html
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Drug Discovery using Complex In Vitro Models (CIVMs) | AI Image Analysis

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